A Short Note On The And Its Effects On Breast Cancer Tissue

3.1. MiR-206 was prominently downregulated in TNBC tissues and inversely correlated with VEGF Quantitative RT-PCR results show that expression levels of miR-206 are obviously lower in TNBC cell lines than those in non-TNBC cell lines (Fig. 1A). Similarly, TNBC tissues express prominently lower levels of miR-206 compared to non-TNBC tissue samples and normal breast tissues (Fig. 1B). It is worth noting that non-TNBC tissues expressed lower miR-206 compared to normal breast tissues but miR-206 levels in non-TNBC tissues were higher than those in TNBC tissues (Fig. 1B). Furthermore, we analyzed the expression levels of VEGF protein determined by immunohistochemical staining in breast cancer tissue samples. VEGF expression levels were inversely correlated with those of miR-206 in breast cancer tissues (Fig. 1C). These results demonstrate that expression levels of miR-206 are predominantly downregulated in TNBC tissues in comparison to non-TNBC tissues and normal breast tissue samples inv ersely correlated with the levels of VEGF. 3.2. MiR-206 mimics predominantly inhibit the invasion of TNBC cells in vitro To investigate whether miR-206 mimics block the invasion of TNBC cells, miR-206 mimics or control oligonucleotides were transfected into TNBC MDA-MB-231 and non-TNBC MCF-7 cells. The invasive cells from treated groups were determined and compared to their controls by Matrigel invasion assay. Fig 2A shows representatives of invasive cell photographs fromShow MoreRelatedThe Importance Of Staying Healthy And Preventative Measures1551 Words   |  7 Pagescorrelating symptoms. For example, aflatoxins, the most common classification of mycotoxins, are the primary cause of liver and kidney cancer especially in poor countries (Aiko and Mehta 2) (Hope 1). 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